Our Research

BioRender created image of the inside of a bacterial cell model of how a sensor kinase activates a response regulator. Additionally, it shows how this regulation can activate the transcription of genes through the use of arrows from the response regulator to the Promoter arrow. There is also a small protein the membrane with a question mark under a dotted line leading back to the sensor kinase.

Unveiling the Role of Small Proteins in Model Organisms

We look to elucidate the mechanisms through which small proteins, approximately 50 amino acids in length, contribute to the regulation of stress responses in bacteria, with a particular focus on E. coli and B. subtilis. Our research revolves around exploring the role of these small proteins in modulating two-component systems, which serve as vital sensory and adaptive mechanisms in response to diverse external stimuli.

 

Identifying Regulatory Small Proteins 

We recognize that there is a need for efficient functional characterization methods for small proteins. With over 100 small proteins already identified in E. coli, the process of determining their functionality is laborious. Hence, we are dedicated to developing and evaluating a novel screening methodology that not only expedites the identification of functional small proteins but also places special emphasis on those involved in regulating two-component systems, thus shedding light on their crucial role in bacterial adaptation.